On Apr 27, 5:17 am, SmileDomain <enthume...@[EMAIL PROTECTED]
> wrote:
> Recently I am working to do a meta-analysis on some kind of gene-
> disease. Since there are only two studies include in my work, it is
> impossible to do a meta-regression. And the fixed effected model and
> radom affected model are useless too. There are few studies focusing
> on this topic, can any one give a sugguestion?
What prevents you from computing a pooled estimate in the usual
fa****on? If I'm not mistaken, the usual chi-square test of
heterogeneity would be equivalent to the square of a z-test comparing
the estimates from the two individual studies.
> ps. I have not only the published data, but also the original data.
> But they are so different, one meet the HWE perfectly, while the Chi-2
> of another study is larger than 10.
What is HWE? What kind of data are you talking about? Odds ratios
from 2x2 tables? Or something else?
--
Bruce Weaver
bweaver@[EMAIL PROTECTED]
"When all else fails, RTFM."
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